Subject: Postdoctoral Fellow (Behavioral & Neurobiological Research) - 213821

Description:
Join the HJF Team!

The Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. (HJF) is seeking a Postdoctoral Fellow for the Department of
Pharmacology & Molecular Therapeutics, located at the Uniformed Services
University of the Health Sciences (USUHS) in Bethesda, Maryland.  HJF
provides scientific, technical and programmatic support services to USUHS.
The incumbent will work in the laboratory of Dr. Irwin Lucki and Dr. Caroline
Browne, to evaluate the therapeutic potential of ketamine and kappa opioid
receptor (KOR) antagonists currently under development for the clinical
treatment of depression and anxiety disorders. The successful candidate will
utilize site-specific injections of KOR ligands and viral technology to
knockdown opioid receptors in a region specific manner, ultimately defining a
neural circuit activated by chronic stress where novel antidepressants can
intervene and mollify the effects of stress on behavior.

Job Requirements:

Please send a letter detailing your experience to date and your interest in
the position, together with your C.V. to Dr. Caroline Browne,
[log in to unmask] After emailing your C.V. please apply to the
position (below) so that we can track your application.

Responsibilities:
•The employee will work with and under the supervision of Dr. Irwin Lucki
and Dr. Caroline Browne on translational preclinical research projects to
discern the involvement of KOR in producing anhedonia and negative affect in
mice following exposure to chronic stress
•Independently conduct behavioral and neurobiological research studies by
completing literature searches; developing hypotheses; planning and
conducting experiments and tests; recording, organizing and analyzing
findings; developing conclusions.
•Develop written and oral communications skills, including formulating and
writing manuscripts, proposals and presentation of findings at national and
international meetings
•Perform a wide variety of behavioral tests and develop new translationally
relevant behavioral models. Conduct stereotaxic surgery and site specific
injections to recapitulate the effects of systemic drug administration in
awake freely moving mice in behavioral tests relevant to stress-induced
depression and anxiety.
•Utilize a wide variety of bench work including microdialysis,
immunohistochemistry, qRT-PCR, and protein quantification.
•Supervise junior research staff to include medical residents, graduate
students and summer interns, to ensure that correct and safe laboratory
procedures are followed; provides direction to assure completion of technical
tasks and projects.

Required Knowledge, Skills, and Abilities: The candidate would ideally have
subject knowledge as reflected by publications in peer-reviewed scientific
journals as appropriate to his/her research. Applicants are expected to have
previous experience in animal handling, stereotaxic surgery, microinjection
and behavioral testing. A good knowledge of pharmacology, microdialysis, and
experience of gene knockdown using adeno-associated virus (AAV) or DREADDs
(designer receptors exclusively activated by designer drugs) would be ideal.

Minimum Education/Training Requirements: Ph.D. in neuroscience, pharmacology
or related discipline.

Minimum Experience: 0 – 2 years of experience post Ph.D.

Physical Capabilities:  Position involves exposure to chemicals, biological
materials, and rodents in a laboratory setting.  Long periods of standing
and/or walking may be required.

Work Environment: Behavioral psychopharmacology research and development
laboratory. Uniformed Services University is the federal military medical
university in the suburbs of Washington DC. We are located on the grounds of
Walter Reed National Military Medical Center, across the road from the
National Institutes of Health in Bethesda, MD.

HJF is an equal opportunity and affirmative action employer.  All qualified
applicants will receive consideration for employment without regard to race,
color, religion, sex, sexual orientation, gender identity, national origin,
disability, or protected veteran status.

Any qualifications to be considered as equivalents, in lieu of stated
minimums, require the prior approval of the Director of Human Resources.


Contact Person: CHRISTINE SAINT-AMAND
Contact Email: [log in to unmask]
Website URL:
https://careers.hjf.org/jobs/2684703-postdoctoral-fellow-behavioral-and-neurobiological-research

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