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April 2014

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Subject:
From:
Charles Papageorgiou <[log in to unmask]>
Reply To:
Charles Papageorgiou <[log in to unmask]>
Date:
Sat, 12 Apr 2014 09:54:37 -0400
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multipart/mixed
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Takeda Pharmaceuticals International Co. currently has an opening for a 
post-doctoral fellow within the Chemical Development Laboratories (CDL) at 
its Boston, MA location.  The position is a 2 year assignment renewable 
for a 3rd year upon mutual agreement. The successful candidate will be a 
chemical engineer with experience in the field of small molecule 
crystallization responsible for the development and scale-up of continuous 
crystallization manufacturing processes.

In CDL, cost-effective processes for the manufacture of new small molecule 
pharmaceuticals are conceived and developed along with methods for 
achieving and controlling high standards of purity. The process 
development chemists supply bulk drug substance (DS) to support clinical 
trials of Takeda’s experimental drugs through the development and 
implementation of synthetic manufacturing processes. They interact with a 
broad spectrum of research and development groups throughout the life of a 
compound and lead the technical transfer of chemical processes, evaluate 
process safety, characterize materials and conduct reaction engineering 
work. The group is also involved in the making of material to support 
safety and bioavailability studies. 

CDL operates in a dynamic team fashion; organized to provide high quality 
laboratory development, project leadership, CRO management and safety and 
environmental assessments.

The postdoctoral fellow will utilize all available tools (including 
process analytical technologies/ PAT, statistical analysis, computational 
modeling and automated reaction optimization) to characterize batch 
crystallization processes and determine the critical process parameters. 
He/ she will be responsible for converting existing batch crystallization 
processes to continuous as well as designing and characterizing suitable 
laboratory and pilot-plant scale continuous crystallizers.


DUTIES & RESPONSIBILITIES	•	Develop and optimize 
crystallization processes
•	Design of laboratory and pilot-plant scale continuous crystallizers
•	Use computational modeling software
•	Use PAT both to gain understanding of crystallization processes as 
well as to monitor and control productions
•	Manufacture drug substance on kilogram scale internally using the 
developed continuous crystallizer
•	Communicate work to supervisor and co-workers both locally and 
globally
•	Author and review technical reports and publications in 
internationally acclaimed journals
•	Present research results both internally and externally
QUALIFICATIONS	•	PhD in Chemical Engineering or related discipline 
with 0-3 years of postdoctoral training in academia or industry.


The successful candidate will demonstrate:
•	Strong technical proficiency 
•	Scientific creativity
•	Ability to collaborate with others
•	Ability to work independently, 
•	Strong organizational skills.  

In addition the preferred candidate will have:

•	Familiarity in the use of common analytical and physical 
characterization techniques (XRPD, DSC, TGA, IR, Raman, FBRM, NMR, 
microscopy, particle size, HPLC, GC, MS) and interpretation of the results.
•	Experience in designing and scaling-up crystallization processes 
based upon above generated data
•	Experience in continuous manufacturing
•	Experience in equipment design
•	Experience in computational fluid dynamics (CFD) analysis

Interested parties can apply online (www.takeda.com) or contact Charles 
Papageorgiou at [log in to unmask] or +1-617-577-3549 for 
more information



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