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January 2010

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From:
Demetri Petrides <[log in to unmask]>
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Date:
Sat, 9 Jan 2010 10:38:39 -0500
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Dear Colleagues,

We have scheduled a number of two-day courses on batch process modeling,
cost of goods analysis, production scheduling, capacity analysis, cycle time
reduction, debottlenecking, and waste minimization at various Universities
around the globe. The courses are intended for scientists and engineers in
the Pharmaceutical, Biotech, Fine Chemical, Bio-fuel, Food, and Consumer
Product industries that are interested in:

* Modeling and Optimization of Batch and Continuous Processes
* Cost of Goods Analysis 
* Cycle Time Reduction and Debottlenecking
* Production Planning and Scheduling
* Capacity Analysis
* Variability Reduction
* Lean Manufacturing

The courses include theory on the above subjects and hands-on sessions with
process simulation and scheduling tools that facilitate the above tasks.
The courses are taught by experts from industry and academia.

Instructors at colleges and universities that teach Biochemical Engineering,
Pharmaceutical Engineering, Process and Plant Design, Food Engineering, and
related courses are welcome to attend.

UPCOMING COURSES  - DATES AND VENUES

USA, San Francisco, CA, January 13-14, 2010
San Jose State University
Dept. of Chemical Engineering
One Washington Square
San Jose, CA 95192-0082

INDIA, Pune, February 22-23, 2010
Rajiv Gandhi Institute of IT and BT
Bharati Vidyapeeth Univresity
Katraj, Pune - 411046, Maharashtra, India

USA, New Jersey, March 18-19, 2010
Rutgers University
Dept of Chemical & Biochemical Engineering
98 Brett Rd
Piscataway, NJ 08854-8058

Belgium, Antwerpen, end of April 2010
Karel de Grote - Hogeschool
Chemical Department
Salesianenlaan 30
B-2660 Hoboken, Belgium

USA, Raleigh, NC, May 13-14, 2010
North Carolina State University
Biomanufacturing Training & Education Center (BTEC)
Raleigh, NC 27695-7905

USA, Boston, MA, June 7-9, 2010
Tufts University
Chemical and Biological Engineering
4 Colby Street
Medford, MA  02155

BRAZIL, Sao Paulo, end of September, 2010
CTBE - Bioethanol Science & Techn. Center
Caixa Postal 6170
13083-970 Campinas, SP 
BRAZIL

You may register for a course by responding to this message. 

SIMILAR COURSES WILL BE OFFERED IN OTHER PARTS OF THE WORLD. For additional
venues and dates, please point your browser to:
<http://www.intelligen.com/training.shtml>
http://www.intelligen.com/training.shtml

PLEASE FORWARD THIS MESSAGE TO ANY OF YOUR COLLEAGUES THAT MAY HAVE AN
INTEREST IN THE SUBJECT.

If you have any questions, please do not hesitate to contact me.

Best Regards,

Demetri Petrides, Ph.D.
President
INTELLIGEN, INC.
2326 Morse Avenue
Scotch Plains, NJ 07076
Tel: (908) 654-0088
Mobile: (908) 397-7507
Fax: (908) 654-3866
Email: [log in to unmask]
 <http://www.intelligen.com> http://www.intelligen.com

=====================================
AGENDA FOR THE TWO-DAY WORKSHOPS
=====================================

FIRST DAY
==================
MORNING SESSION
9:00 - 9:45 AM  - Introduction to Process Simulation
9:45 - 10:30 AM - Flowsheet Development and Initialization
10:30 - 10:45 AM - Tea / Coffee Break
10:45 - 12:00 Noon - Material Balances & Equipment Sizing

12:00 - 1:00 PM - Lunch Break

AFTERNOON SESSION
1:00 - 2:00 PM - Process Scheduling & Resource Tracking
2:00 - 3:00 PM - Cycle Time Reduction & Debottlenecking
3:00 - 3:30 PM - Tea / Coffee Break
3:30 - 5:00 PM - Production Planning & Capacity Analysis

SECOND DAY
====================
MORNING SESSION
9:00 - 10:30 AM  - Project Economic Evaluation
10:30 - 11:00 AM - Tea / Coffee Break
11:00 - 12:00 Noon - Lean Manufacturing

12:00 - 1:00 PM - Lunch Break

AFTERNOON SESSION
1:00 - 2:00 PM - Environmental Impact Assessment
2:00 - 3:00 PM - Wastewater Treatment and Purification
3:00 - 3:30 PM - Tea / Coffee Break
3:30 - 5:00 PM - Q&A and Miscellaneous Topics

The contents of the courses are often adjusted to meet the specific needs of
the attendees.

  _____  

IF YOU CANNOT ATTEND OUR WORKSHOPS BUT ARE INTERESTED IN THE ABOVE SUBJECTS,
YOU MAY WANT TO VISIT OUR WEBSITE ( <http://www.intelligen.com>
http://www.intelligen.com) AND DOWNLOAD THE FOLLOWING:

1) The functional Evaluation versions of SuperPro Designer and SchedulePro.

2) A book chapter on The Role of Simulation and Scheduling Tools in the
Development and Manufacturing of Active Pharmaceutical Ingredients. An
improved version of this document will become available as a chapter of a
new book on "Chemical Engineering in the Pharmaceutical Industry: From R&D
to Manufactiuring" that will be published by John Wiley & Sons in 2010. The
focus of this article is on small molecule active pharmaceutical ingredients
(APIs). 

3) A book chapter on Bioprocess Design and Economics. This is useful
material for professionals in biotechnology and biochemical engineering
professors. It provides valuable introductory material on bioprocess design
and three thorough case studies on: i) Citric Acid, ii) Biosynthetic Human
Insulin (Eli Lilly's process), and iii) Therapeutic Monoclonal Antibodies.
The complete book can be purchased from Oxford University Press (
<http://www.oup-usa.org/isbn/0195123409.html>
http://www.oup-usa.org/isbn/0195123409.html).

4) A paper on the Systematic Evaluation of Single-Use Systems Using Process
Simulation Tools. A version of this article appeared in the November, 2008,
Guide to Disposables, a supplement to BioPharm International. This article
evaluates the impact of single-use systems (disposables) on production cost,
demand for cleaning materials, demand for consumables, and production cycle
time. The analysis is done for a typical cell culture facility producing
therapeutic monoclonal antibodies. The SuperPro models used for this example
also can be downloaded from the same page of our website. 

5) A paper on The Role of Simulation and Scheduling Tools in the Development
and Manufacture of Pharmaceutical Products. This article appeared in the
July 2007 issue of Chemical Engineering Research and Design (an IChemE
publication). It provides information on the benefits from the use of
process simulation and finite capacity scheduling tools in the development
and manufacture of pharmaceutical products. An illustrative example focusing
on Tablet Manufacturing is included. Topics covered in the article include:
Materials Balances, Cost of Goods Analysis, Cycle Time Analysis and
Reduction, Uncertainty and Variability Analysis, Production Planning and
Scheduling.

6) A paper on Risk Assessment, Variability Analysis, and Monte Carlo
Simulation.  

7) A paper on Corn to Ethanol Conversion written by scientists at a Research
Center of USDA. The process was modeled and evaluated using SuperPro
Designer. The SuperPro file also can be downloaded from our website. 

8) A paper on Bio-diesel Production written by scientists at a Research
Center of USDA. The process was modeled and evaluated using SuperPro
Designer. The SuperPro file also can be downloaded from our website. 

9) A paper on THROUGHPUT ANALYSIS AND DEBOTTLENECKING OF BIOMANUFACTURING
FACILITIES. This article was published in the August, 2002, issue of
BioPharm. It focuses on debottlenecking and cycle time reduction of
monoclonal antibody production processes.

10) A Powerpoint file on THROUGHPUT ANALYSIS, DEBOTTLENECKING, AND ECONOMIC
EVALUATION OF INTEGRATED BIOCHEMICAL PROCESSES. The presentation includes
introductory material on process modeling, theory on throughput analysis and
debottlenecking, an example based on a biopharmaceutical process, and cost
analysis results. The complete text of the presentation can be found in the
"Notes" page of the slides. This is valuable material for professionals in
the biopharmaceutical industry that deal with process development and
product commercialization.

11) A Powerpoint file on THROUGHPUT ANALYSIS AND TECHNOLOGY TRANSFER of a
synthetic pharmaceutical process. The complete text of the presentation can
be found in the "Notes" page of the slides. This is valuable material for
professionals in the pharmaceutical and specialty chemical industries that
deal with process development and manufacturing.

12) A paper and a Powerpoint file on "EVALUATION OF WATER RECYCLING OPTIONS
AT A SEMICONDUCTOR FABRICATION PLANT USING PROCESS SIMULATION". The
principles and ideas can be readily extended to any other industrial
facility that utilizes large amounts of water and has a need for recycling.

13) A Powerpoint file on VISUALIZATION AND DEBOTTLENECKING OF PRODUCT
FORMULATION AND PACKAGING PROCESSES. It is applicable to professionals in
the food, consumer product, pharmaceutical, beverage, and related
industries. Essentially, whenever there is a combination of batch and
semi-continuous processing steps that share equipment across product lines,
SuperPro can be used to reduce cycle times and increase plant throughput.

14) A paper on THE ROLE OF PROCESS SIMULATION IN PHARMACEUTICAL PROCESS
DEVELOPMENT AND PRODUCT COMMERCIALIZATION. This paper appeared in the
Jan/Feb, 2002, issue of Pharmaceutical Engineering (the main publication of
ISPE). It provides info on the role of batch process simulators in
facilitating development and commercialization of bulk pharmaceuticals.

RECOMMENDED TEXTBOOKS

Bioseparations Science and Engineering
Many of you downloaded in the past my book chapter on Bioprocess Design and
Economics. You may now purchase the entire book from Oxford University Press
(just point your browser to:  <http://www.oup-usa.org/isbn/0195123409.html>
http://www.oup-usa.org/isbn/0195123409.html or go to amazon.com and search
based on the title). The original chapter on Design and Economics can still
be downloaded (free of charge) from our website (
<http://www.intelligen.com/literature.shtml>
http://www.intelligen.com/literature.shtml).

Development of Sustainable Bioprocesses: Modeling and Assessment 
by Elmar Heinzle, Arno P. Biwer, and Charles Cooney, John Wiley & Sons,
2006. This book includes 11 bioprocesses modeled and analyzed with SuperPro
Designer. The SuperPro files of the 11 bioprocesses are available on a CD
that is shipped with the book. You may purchase the book from the publisher
http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470015594.html?cid=RSS_W
ILEY2_LIFEMED or at a discount from Amazon.com. 



































































 



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