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February 2010


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Frank Doyle <[log in to unmask]>
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Frank Doyle <[log in to unmask]>
Sat, 6 Feb 2010 11:03:41 -0500
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i) Systems Biology/Circadian Rhythms
ii) Biomedical Engineering/Diabetes

Departments of Chemical Engineering  and  Biomolecular Science & 
University of California, Santa Barbara

There are two project openings, to be filled immediately, in the following 

i) Systems Biology of Coupled Oscillations in Circadian Rhythm Generation 
(NIH and ARO funded)

The proposed research will yield an improved understanding of the 
organizational principles of coupled biological oscillators and provide 
insights into circadian disorders that adversely affect human sleep, 
physiology and cognitive functioning.  The assembled research team is 
comprised of an experimental biologist with expertise in the intracellular 
and intercellular processes responsible for mammalian circadian rhythm 
generation and synchronization, chemical engineers with expertise in 
developing and analyzing mathematical models of gene regulatory and signal 
transduction networks and of large systems of coupled biological 
oscillators, a numerical analyst with expertise in deterministic and 
stochastic simulation and the development of professional grade simulation 
codes, and an applied mathematician with expertise in large interacting 
systems and nonlinear stochastic partial differential equations.

ii) Control Algorithm Design for an Artificial Pancreas (NIH and JDRF 

This project seeks to combine continuous glucose sensing with automated 
insulin delivery in a closed-loop system in order to achieve glucose 
normalization in subjects with type 1 diabetes. The end result of this 
line of research will be an artificial pancreas that will provide around-
the-clock glucose regulation through electronically-controlled short- and 
long-term insulin delivery in response to detected patterns of change in 
glucose levels. Algorithm design and mathematical modeling are aims for 
the engineering component of the project. The project involves 
collaborations with medical doctors who will conduct the clinical trials.

Candidates for either position should have a Ph.D. Degree in Chemical 
Engineering, Bioengineering, or related disciplines with experience or 
extensive exposure to mathematical modeling, systems biology, control and 
dynamics. Strong oral and written communication skills are a requisite.

UCSB offers competitive salary and benefits. Applicants should send a CV, 
a statement of their professional interests (not longer than 1 page) and 
the names, e-mail addresses of at least three technical references to:

Professor Francis J. Doyle III
Department of Chemical Engineering
University of California, Santa Barbara
Santa Barbara, CA 93106-5080

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Submission of application material by e-mail is strongly encouraged.