Takeda Pharmaceuticals International Co. currently has an opening for a
post-doctoral fellow within the Chemical Development Laboratories (CDL) at
its Boston, MA location. The position is a 2 year assignment renewable
for a 3rd year upon mutual agreement. The successful candidate will be a
chemical engineer with experience in the field of small molecule
crystallization responsible for the development and scale-up of continuous
crystallization manufacturing processes.
In CDL, cost-effective processes for the manufacture of new small molecule
pharmaceuticals are conceived and developed along with methods for
achieving and controlling high standards of purity. The process
development chemists supply bulk drug substance (DS) to support clinical
trials of Takedas experimental drugs through the development and
implementation of synthetic manufacturing processes. They interact with a
broad spectrum of research and development groups throughout the life of a
compound and lead the technical transfer of chemical processes, evaluate
process safety, characterize materials and conduct reaction engineering
work. The group is also involved in the making of material to support
safety and bioavailability studies.
CDL operates in a dynamic team fashion; organized to provide high quality
laboratory development, project leadership, CRO management and safety and
The postdoctoral fellow will utilize all available tools (including
process analytical technologies/ PAT, statistical analysis, computational
modeling and automated reaction optimization) to characterize batch
crystallization processes and determine the critical process parameters.
He/ she will be responsible for converting existing batch crystallization
processes to continuous as well as designing and characterizing suitable
laboratory and pilot-plant scale continuous crystallizers.
DUTIES & RESPONSIBILITIES Develop and optimize
Design of laboratory and pilot-plant scale continuous crystallizers
Use computational modeling software
Use PAT both to gain understanding of crystallization processes as
well as to monitor and control productions
Manufacture drug substance on kilogram scale internally using the
developed continuous crystallizer
Communicate work to supervisor and co-workers both locally and
Author and review technical reports and publications in
internationally acclaimed journals
Present research results both internally and externally
QUALIFICATIONS PhD in Chemical Engineering or related discipline
with 0-3 years of postdoctoral training in academia or industry.
The successful candidate will demonstrate:
Strong technical proficiency
Ability to collaborate with others
Ability to work independently,
Strong organizational skills.
In addition the preferred candidate will have:
Familiarity in the use of common analytical and physical
characterization techniques (XRPD, DSC, TGA, IR, Raman, FBRM, NMR,
microscopy, particle size, HPLC, GC, MS) and interpretation of the results.
Experience in designing and scaling-up crystallization processes
based upon above generated data
Experience in continuous manufacturing
Experience in equipment design
Experience in computational fluid dynamics (CFD) analysis
Interested parties can apply online (www.takeda.com) or contact Charles
Papageorgiou at [log in to unmask] or +1-617-577-3549 for