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CAST10  November 2019

CAST10 November 2019

Subject:

Postdoctoral Fellow on Modeling & Simulation at Amgen, Cambridge, MA (USA)

From:

Pablo A Rolandi <[log in to unmask]>

Reply-To:

Pablo A Rolandi <[log in to unmask]>

Date:

Tue, 19 Nov 2019 22:07:14 -0500

Content-Type:

text/plain

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text/plain (41 lines)

The Amgen Postdoctoral Program is committed to providing future scientists with an enriched environment to inspire innovation that will contribute to the development of human therapeutics.

Dr. Pablo Rolandi Digital from Integration and Predictive Technologies department at Amgen, Inc. is seeking a Postdoctoral Fellow in advanced computational modeling techniques for risk analysis and quantification based on equation-based, mechanistic and data-driven mathematical models of processes, products and devices.

Risk-based assessments are an integral part of drug/device Process Development methodologies in the biopharmaceutical industry. Conventional risk assessment techniques are mostly heuristic and subjective, and they give rise to largely qualitative assessments. Calculation of risk probabilities, which are particularly important for rare yet serious incidents, is difficult to accomplish in practice. These factors combined lead to lack of reliability and increased design and/or operating/manufacturing costs. The need for more rigorous risk analysis frameworks becomes more important as available data sets are scarce or platform knowledge is not available, and first-principles models fill this empirical gap, or, conversely, where data is abundant and enables the creation of sophisticated multi-factor and multi-feature machine-learning models.

The candidate will develop and apply mathematical modeling techniques transform risk assessments from a qualitative methodology to a semi- or fully-quantitative one. The research will exploit first principles modeling, machine learning, uncertainty quantification and Bayesian inference to achieve the desired goal. The research will leverage existing model assets in Amgen’s Process Development organization, and benefit all functional organizations (attributes, drug substance/product, devices, chemistry manufacturing and controls). Applications will also involve different modalities (biologics and synthetics), and encompass both single unit operations or device components, as well as process systems or combination products, Quality and Regulatory Affairs are likely stakeholders too.

This research will yield a methodology for robust design of products, processes and devices with a focus on techno-economic risk, agility and reliability. Another important outcome of this work will be a faster and more reliable development of in-silico models. This research is aligned with several Process Development and Operations strategic initiatives. The researcher will collaborate with word-class investigators in this field. Manuscript publication and meeting presentations will occur immediately with the outcomes of the study. 

The assignment length is expected to be 2 years long with the option to extend for 1 additional year.

Basic Qualifications
 * PhD at the time of appointment

Preferred Qualifications
 * PhD in (Bio)Chemical Engineering, (Bio)Mechanical Engineering, Applied Physics or Applied Mathematics
 * Publications in uncertainty quantification, Bayesian inference, surrogate modeling or mathematical programming
 * Proficiency in programming languages: Python and C/C++
 * Familiarity with ANSYS, COMSOL, gPROMS or Pyomo
 * Familiarity with the Python scientific computing tech-stack (numpy, scipy, scikit-learn, NumFOCUS, etc)

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment regardless of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Join Us
If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.​

Apply
Submit your application here: https://careers.amgen.com/ShowJob/JobId/296964/Postdoctoral-Fellow-Modeling-Simulation

Category: Postdoctoral
Job ID: R-78037
Location: Cambridge, MA, US 02139
Additional Location:
Posted Date: 6/7/2019

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