POSTDOCTORAL POSITIONS i) Systems Biology/Circadian Rhythms ii) Biomedical Engineering/Diabetes Departments of Chemical Engineering and Biomolecular Science & Engineering University of California, Santa Barbara There are two project openings, to be filled immediately, in the following areas: i) Systems Biology of Coupled Oscillations in Circadian Rhythm Generation (NIH and ARO funded) The proposed research will yield an improved understanding of the organizational principles of coupled biological oscillators and provide insights into circadian disorders that adversely affect human sleep, physiology and cognitive functioning. The assembled research team is comprised of an experimental biologist with expertise in the intracellular and intercellular processes responsible for mammalian circadian rhythm generation and synchronization, chemical engineers with expertise in developing and analyzing mathematical models of gene regulatory and signal transduction networks and of large systems of coupled biological oscillators, a numerical analyst with expertise in deterministic and stochastic simulation and the development of professional grade simulation codes, and an applied mathematician with expertise in large interacting systems and nonlinear stochastic partial differential equations. ii) Control Algorithm Design for an Artificial Pancreas (NIH and JDRF funded) This project seeks to combine continuous glucose sensing with automated insulin delivery in a closed-loop system in order to achieve glucose normalization in subjects with type 1 diabetes. The end result of this line of research will be an artificial pancreas that will provide around- the-clock glucose regulation through electronically-controlled short- and long-term insulin delivery in response to detected patterns of change in glucose levels. Algorithm design and mathematical modeling are aims for the engineering component of the project. The project involves collaborations with medical doctors who will conduct the clinical trials. Candidates for either position should have a Ph.D. Degree in Chemical Engineering, Bioengineering, or related disciplines with experience or extensive exposure to mathematical modeling, systems biology, control and dynamics. Strong oral and written communication skills are a requisite. UCSB offers competitive salary and benefits. Applicants should send a CV, a statement of their professional interests (not longer than 1 page) and the names, e-mail addresses of at least three technical references to: Professor Francis J. Doyle III Department of Chemical Engineering University of California, Santa Barbara Santa Barbara, CA 93106-5080 [log in to unmask] Submission of application material by e-mail is strongly encouraged.