Dear
Colleagues,
We have
scheduled a number of two-day workshops on batch process modeling, cost of goods
analysis, production scheduling, capacity analysis, cycle time reduction,
debottlenecking, and waste minimization at various
Universities around the globe. The workshops are intended for scientists and
engineers in the Pharmaceutical, Biotech, Fine Chemical, Bio-fuel, Food, and Consumer
Product industries that are interested in:
* Modeling and
Optimization of Batch and Continuous Processes
* Cost of Goods Analysis
* Cycle Time Reduction
and Debottlenecking
* Production Planning
and Scheduling
* Capacity Analysis
* Variability Reduction
* Lean Manufacturing
The workshops include theory on the above subjects and hands-on sessions with
process simulation and scheduling tools that facilitate the above tasks.
They are taught by experts from industry and academia.
Instructors at colleges and universities that teach Biochemical Engineering,
Pharmaceutical Engineering, Process and Plant Design, Food Engineering, and
related courses are welcome to attend.
UPCOMING WORKSHOPS
- DATES AND VENUES
USA, New Jersey, March 18-19, 2010
Rutgers University
Dept of Chemical & Biochemical Engineering
98 Brett Rd
Piscataway, NJ 08854-8058
Belgium,
Antwerpen, April 20-21, 2010
Karel de Grote - Hogeschool
Chemical Department
Salesianenlaan 30
B-2660 Hoboken, Belgium
USA,
Raleigh, NC, May 13-14, 2010
North Carolina State University
Biomanufacturing Training & Education Center (BTEC)
Raleigh, NC 27695-7905
USA,
Boston, MA, June 7-9, 2010
Tufts University
Chemical and Biological Engineering
4 Colby Street
Medford, MA 02155
BRAZIL,
Sao Paulo, end of September, 2010
CTBE - Bioethanol Science & Techn. Center
Caixa Postal 6170
13083-970 Campinas, SP
BRAZIL
USA, West
Lafayette, IN, October 11-12, 2010
Purdue University
Agricultural and Bio Engineering
225 S University Street
West Lafayette, IN 47907-1146
The
Netherlands, Delft, end of October 2010
TU Delft
Dept of Biotechnology
Julianalaan 67
2628 BC Delft, The Netherlands
You may
register for a course by responding to this message.
SIMILAR WORKSHOPS WILL BE OFFERED IN OTHER PARTS OF THE WORLD. For additional
venues and dates, please point your browser to: http://www.intelligen.com/training.shtml
PLEASE FORWARD THIS
MESSAGE TO ANY OF YOUR COLLEAGUES THAT MAY HAVE AN INTEREST IN THE SUBJECT.
If you have any questions, please do not hesitate to contact me.
Best Regards,
Demetri Petrides, Ph.D.
President
INTELLIGEN, INC.
2326 Morse Avenue
Scotch Plains, NJ 07076
Tel: (908) 654-0088
Mobile: (908) 397-7507
Fax: (908) 654-3866
Email: [log in to unmask]
http://www.intelligen.com
=====================================
AGENDA FOR THE TWO-DAY
WORKSHOPS
=====================================
FIRST DAY
==================
MORNING SESSION
9:00 - 9:45 AM - Introduction to Process Simulation
9:45 - 10:30 AM - Flowsheet Development and Initialization
10:30 - 10:45 AM - Tea / Coffee Break
10:45 - 12:00 Noon - Material Balances & Equipment Sizing
12:00 - 1:00 PM - Lunch Break
AFTERNOON SESSION
1:00 - 2:00 PM - Process Scheduling & Resource Tracking
2:00 - 3:00 PM - Cycle Time Reduction & Debottlenecking
3:00 - 3:30 PM - Tea / Coffee Break
3:30 - 5:00 PM - Production Planning & Capacity Analysis
SECOND DAY
====================
MORNING SESSION
9:00 - 10:30 AM - Project Economic Evaluation
10:30 - 11:00 AM - Tea / Coffee Break
11:00 - 12:00 Noon - Lean Manufacturing
12:00 - 1:00 PM - Lunch Break
AFTERNOON SESSION
1:00 - 2:00 PM - Environmental Impact Assessment
2:00 - 3:00 PM - Wastewater Treatment and Purification
3:00 - 3:30 PM - Tea / Coffee Break
3:30 - 5:00 PM - Q&A and Miscellaneous Topics
The contents of the courses are often adjusted to meet the specific needs of
the attendees.
IF YOU
CANNOT ATTEND OUR WORKSHOPS BUT ARE INTERESTED IN THE ABOVE SUBJECTS, YOU MAY
WANT TO VISIT OUR WEBSITE (http://www.intelligen.com) AND DOWNLOAD THE
FOLLOWING:
1) The functional Evaluation versions of SuperPro Designer and SchedulePro.
2) A paper on the Design and Optimization of a
Large Scale Biopharmaceutical Facility using Process Simulation and Scheduling
Tools. An improved version of this
article will be published in the March / April 2010 issue of Pharmaceutical
Engineering (the ISPE magazine).
3) A book
chapter on The Role of Simulation and Scheduling
Tools in the Development and Manufacturing of Active Pharmaceutical Ingredients.
An improved version of this document will become
available as a chapter of a new book on “Chemical Engineering in the
Pharmaceutical Industry: From R&D to Manufactiuring” that will be
published by John Wiley & Sons in 2010. The focus of this article is on
small molecule active pharmaceutical ingredients (APIs).
4) A book chapter on Bioprocess Design and
Economics. This is useful material for professionals in
biotechnology and biochemical engineering professors. It provides valuable
introductory material on bioprocess design and three thorough case studies on:
i) Citric Acid, ii) Biosynthetic Human Insulin (Eli Lilly's process), and iii)
Therapeutic Monoclonal Antibodies. The complete book can be purchased from
Oxford University Press (http://www.oup-usa.org/isbn/0195123409.html).
5) A paper
on the Systematic Evaluation of Single-Use
Systems Using Process Simulation Tools. A version of this article
appeared in the November, 2008, Guide to Disposables, a supplement to
BioPharm International. This article evaluates the impact of single-use systems
(disposables) on production cost, demand for cleaning materials, demand for
consumables, and production cycle time. The analysis is done for a typical cell
culture facility producing therapeutic monoclonal antibodies. The SuperPro
models used for this example also can be downloaded from the same page of our
website.
6) A paper
on The Role of Simulation and Scheduling Tools in
the Development and Manufacture of Pharmaceutical Products. This
article appeared in the July 2007 issue of Chemical Engineering Research and
Design (an IChemE publication). It provides information on the benefits from
the use of process simulation and finite capacity scheduling tools in the
development and manufacture of pharmaceutical products. An illustrative example
focusing on Tablet Manufacturing is included. Topics covered in the article
include: Materials Balances, Cost of Goods Analysis, Cycle Time Analysis and
Reduction, Uncertainty and Variability Analysis, Production Planning and
Scheduling.
7) A paper
on Risk Assessment, Variability Analysis, and
Monte Carlo Simulation.
8) A paper on Corn to Ethanol Conversion
written by scientists at a Research Center of USDA. The process was modeled and
evaluated using SuperPro Designer. The SuperPro file also can be downloaded
from our website.
9) A paper on Bio-diesel Production
written by scientists at a Research Center of USDA. The process was modeled and
evaluated using SuperPro Designer. The SuperPro file also can be downloaded
from our website.
10) A paper on THROUGHPUT ANALYSIS AND DEBOTTLENECKING OF BIOMANUFACTURING
FACILITIES. This article was published in the August, 2002, issue of BioPharm.
It focuses on debottlenecking and cycle time reduction of monoclonal antibody
production processes.
11) A Powerpoint file on THROUGHPUT ANALYSIS, DEBOTTLENECKING, AND ECONOMIC
EVALUATION OF INTEGRATED BIOCHEMICAL PROCESSES. The presentation includes
introductory material on process modeling, theory on throughput analysis and
debottlenecking, an example based on a biopharmaceutical process, and cost
analysis results. The complete text of the presentation can be found in the
"Notes" page of the slides. This is valuable material for
professionals in the biopharmaceutical industry that deal with process
development and product commercialization.
12) A Powerpoint file on THROUGHPUT ANALYSIS AND TECHNOLOGY TRANSFER of a
synthetic pharmaceutical process. The complete text of the presentation can be
found in the "Notes" page of the slides. This is valuable material
for professionals in the pharmaceutical and specialty chemical industries that
deal with process development and manufacturing.
13) A paper and a Powerpoint file on "EVALUATION OF WATER RECYCLING
OPTIONS AT A SEMICONDUCTOR FABRICATION PLANT USING PROCESS SIMULATION".
The principles and ideas can be readily extended to any other industrial
facility that utilizes large amounts of water and has a need for recycling.
14) A Powerpoint file on VISUALIZATION AND DEBOTTLENECKING OF PRODUCT
FORMULATION AND PACKAGING PROCESSES. It is applicable to professionals in the
food, consumer product, pharmaceutical, beverage, and related industries.
Essentially, whenever there is a combination of batch and semi-continuous
processing steps that share equipment across product lines, SuperPro can be
used to reduce cycle times and increase plant throughput.
15) A paper on THE ROLE OF PROCESS SIMULATION IN PHARMACEUTICAL PROCESS
DEVELOPMENT AND PRODUCT COMMERCIALIZATION. This paper appeared in the Jan/Feb,
2002, issue of Pharmaceutical Engineering (the main publication of ISPE). It
provides info on the role of batch process simulators in facilitating
development and commercialization of bulk pharmaceuticals.
RECOMMENDED
TEXTBOOKS
Bioseparations
Science and Engineering
Many of you downloaded in the past my book chapter on Bioprocess Design and
Economics. You may now purchase the entire book from Oxford University Press
(just point your browser to: http://www.oup-usa.org/isbn/0195123409.html or go to amazon.com
and search based on the title). The original chapter on Design and Economics
can still be downloaded (free of charge) from our website (http://www.intelligen.com/literature.shtml).
Development of Sustainable Bioprocesses: Modeling
and Assessment
by Elmar Heinzle, Arno P. Biwer, and Charles Cooney, John Wiley & Sons, 2006.
This book includes 11 bioprocesses modeled and analyzed with SuperPro Designer.
The SuperPro files of the 11 bioprocesses are available on a CD that is shipped
with the book. You may purchase the book from the publisher http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470015594.html?cid=RSS_WILEY2_LIFEMED
or at a discount from Amazon.com.