Dear Colleagues,

We have scheduled a number of two-day workshops on batch process modeling, cost of goods analysis, production scheduling, capacity analysis, cycle time reduction, debottlenecking, and waste minimization at various Universities around the globe. The workshops are intended for scientists and engineers in the Pharmaceutical, Biotech, Fine Chemical, Bio-fuel, Food, and Consumer Product industries that are interested in:

* Modeling and Optimization of Batch and Continuous Processes
* Cost of Goods Analysis
* Cycle Time Reduction and Debottlenecking
* Production Planning and Scheduling
* Capacity Analysis
* Variability Reduction
* Lean Manufacturing

The workshops include theory on the above subjects and hands-on sessions with process simulation and scheduling tools that facilitate the above tasks.  They are taught by experts from industry and academia.

Instructors at colleges and universities that teach Biochemical Engineering, Pharmaceutical Engineering, Process and Plant Design, Food Engineering, and related courses are welcome to attend.


USA, New Jersey, March 18-19, 2010
Rutgers University
Dept of Chemical & Biochemical Engineering
98 Brett Rd
Piscataway, NJ 08854-8058

Belgium, Antwerpen, April 20-21, 2010
Karel de Grote - Hogeschool
Chemical Department
Salesianenlaan 30
B-2660 Hoboken, Belgium

USA, Raleigh, NC, May 13-14, 2010
North Carolina State University
Biomanufacturing Training & Education Center (BTEC)
Raleigh, NC 27695-7905

USA, Boston, MA, June 7-9, 2010
Tufts University
Chemical and Biological Engineering
4 Colby Street
Medford, MA  02155

BRAZIL, Sao Paulo, end of September, 2010
CTBE - Bioethanol Science & Techn. Center
Caixa Postal 6170
13083-970 Campinas, SP

USA, West Lafayette, IN, October 11-12, 2010
Purdue University
Agricultural and Bio Engineering
225 S University Street
West Lafayette, IN 47907-1146

The Netherlands, Delft, end of October 2010
TU Delft
Dept of Biotechnology
Julianalaan 67
2628 BC Delft, The Netherlands

You may register for a course by responding to this message.

SIMILAR WORKSHOPS WILL BE OFFERED IN OTHER PARTS OF THE WORLD. For additional venues and dates, please point your browser to:


If you have any questions, please do not hesitate to contact me.

Best Regards,

Demetri Petrides, Ph.D.
2326 Morse Avenue
Scotch Plains, NJ 07076
Tel: (908) 654-0088
Mobile: (908) 397-7507
Fax: (908) 654-3866
Email: [log in to unmask]


9:00 - 9:45 AM  - Introduction to Process Simulation
9:45 - 10:30 AM - Flowsheet Development and Initialization
10:30 - 10:45 AM - Tea / Coffee Break
10:45 - 12:00 Noon - Material Balances & Equipment Sizing

12:00 - 1:00 PM - Lunch Break

1:00 - 2:00 PM - Process Scheduling & Resource Tracking
2:00 - 3:00 PM - Cycle Time Reduction & Debottlenecking
3:00 - 3:30 PM - Tea / Coffee Break
3:30 - 5:00 PM - Production Planning & Capacity Analysis

9:00 - 10:30 AM  - Project Economic Evaluation
10:30 - 11:00 AM - Tea / Coffee Break
11:00 - 12:00 Noon - Lean Manufacturing

12:00 - 1:00 PM - Lunch Break

1:00 - 2:00 PM - Environmental Impact Assessment
2:00 - 3:00 PM - Wastewater Treatment and Purification
3:00 - 3:30 PM - Tea / Coffee Break
3:30 - 5:00 PM - Q&A and Miscellaneous Topics

The contents of the courses are often adjusted to meet the specific needs of the attendees.


1) The functional Evaluation versions of SuperPro Designer and SchedulePro.

2) A paper on the Design and Optimization of a Large Scale Biopharmaceutical Facility using Process Simulation and Scheduling Tools. An improved version of this article will be published in the March / April 2010 issue of Pharmaceutical Engineering (the ISPE magazine).

3) A book chapter on The Role of Simulation and Scheduling Tools in the Development and Manufacturing of Active Pharmaceutical Ingredients. An improved version of this document will become available as a chapter of a new book on “Chemical Engineering in the Pharmaceutical Industry: From R&D to Manufactiuring” that will be published by John Wiley & Sons in 2010. The focus of this article is on small molecule active pharmaceutical ingredients (APIs).

4) A book chapter on Bioprocess Design and Economics. This is useful material for professionals in biotechnology and biochemical engineering professors. It provides valuable introductory material on bioprocess design and three thorough case studies on: i) Citric Acid, ii) Biosynthetic Human Insulin (Eli Lilly's process), and iii) Therapeutic Monoclonal Antibodies. The complete book can be purchased from Oxford University Press (

5) A paper on the Systematic Evaluation of Single-Use Systems Using Process Simulation Tools. A version of this article appeared in the November, 2008, Guide to Disposables, a supplement to BioPharm International. This article evaluates the impact of single-use systems (disposables) on production cost, demand for cleaning materials, demand for consumables, and production cycle time. The analysis is done for a typical cell culture facility producing therapeutic monoclonal antibodies. The SuperPro models used for this example also can be downloaded from the same page of our website.

6) A paper on The Role of Simulation and Scheduling Tools in the Development and Manufacture of Pharmaceutical Products. This article appeared in the July 2007 issue of Chemical Engineering Research and Design (an IChemE publication). It provides information on the benefits from the use of process simulation and finite capacity scheduling tools in the development and manufacture of pharmaceutical products. An illustrative example focusing on Tablet Manufacturing is included. Topics covered in the article include: Materials Balances, Cost of Goods Analysis, Cycle Time Analysis and Reduction, Uncertainty and Variability Analysis, Production Planning and Scheduling.

7) A paper on Risk Assessment, Variability Analysis, and Monte Carlo Simulation

8) A paper on Corn to Ethanol Conversion written by scientists at a Research Center of USDA. The process was modeled and evaluated using SuperPro Designer. The SuperPro file also can be downloaded from our website.

9) A paper on Bio-diesel Production written by scientists at a Research Center of USDA. The process was modeled and evaluated using SuperPro Designer. The SuperPro file also can be downloaded from our website.

10) A paper on THROUGHPUT ANALYSIS AND DEBOTTLENECKING OF BIOMANUFACTURING FACILITIES. This article was published in the August, 2002, issue of BioPharm. It focuses on debottlenecking and cycle time reduction of monoclonal antibody production processes.

11) A Powerpoint file on THROUGHPUT ANALYSIS, DEBOTTLENECKING, AND ECONOMIC EVALUATION OF INTEGRATED BIOCHEMICAL PROCESSES. The presentation includes introductory material on process modeling, theory on throughput analysis and debottlenecking, an example based on a biopharmaceutical process, and cost analysis results. The complete text of the presentation can be found in the "Notes" page of the slides. This is valuable material for professionals in the biopharmaceutical industry that deal with process development and product commercialization.

12) A Powerpoint file on THROUGHPUT ANALYSIS AND TECHNOLOGY TRANSFER of a synthetic pharmaceutical process. The complete text of the presentation can be found in the "Notes" page of the slides. This is valuable material for professionals in the pharmaceutical and specialty chemical industries that deal with process development and manufacturing.

13) A paper and a Powerpoint file on "EVALUATION OF WATER RECYCLING OPTIONS AT A SEMICONDUCTOR FABRICATION PLANT USING PROCESS SIMULATION". The principles and ideas can be readily extended to any other industrial facility that utilizes large amounts of water and has a need for recycling.

14) A Powerpoint file on VISUALIZATION AND DEBOTTLENECKING OF PRODUCT FORMULATION AND PACKAGING PROCESSES. It is applicable to professionals in the food, consumer product, pharmaceutical, beverage, and related industries. Essentially, whenever there is a combination of batch and semi-continuous processing steps that share equipment across product lines, SuperPro can be used to reduce cycle times and increase plant throughput.

15) A paper on THE ROLE OF PROCESS SIMULATION IN PHARMACEUTICAL PROCESS DEVELOPMENT AND PRODUCT COMMERCIALIZATION. This paper appeared in the Jan/Feb, 2002, issue of Pharmaceutical Engineering (the main publication of ISPE). It provides info on the role of batch process simulators in facilitating development and commercialization of bulk pharmaceuticals.


Bioseparations Science and Engineering

Many of you downloaded in the past my book chapter on Bioprocess Design and Economics. You may now purchase the entire book from Oxford University Press (just point your browser to: or go to and search based on the title). The original chapter on Design and Economics can still be downloaded (free of charge) from our website (

Development of Sustainable Bioprocesses: Modeling and Assessment
by Elmar Heinzle, Arno P. Biwer, and Charles Cooney, John Wiley & Sons, 2006. This book includes 11 bioprocesses modeled and analyzed with SuperPro Designer. The SuperPro files of the 11 bioprocesses are available on a CD that is shipped with the book. You may purchase the book from the publisher or at a discount from