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Subject: Summer Internship Opportunity at FDA Description: Project: Consideration of inhalation studies for risk assessment of oral exposure of metals Project Summary: The objective of this project is to evaluate the relevance and significance of data from inhalation studies for risk assessment of oral exposure to metals such as cobalt, nickel and cadmium. This project will involve collection and review of published pharmacokinetic data from the scientific literature for assessment of internal exposure of inhalation versus oral exposure to metals. Furthermore, the collected data will be utilized for building, validating and applying a physiologically-based pharmacokinetic (PBPK) model to perform route to route extrapolation. Skills: The selected candidate will receive training for developing the following skills: • Experience in collection and review of pharmacokinetic data followed by utilization of the data for estimation of pharmacokinetic parameters. • Understanding of basic pharmacokinetic modeling with hands-on exercises using commonly-available pharmacokinetic softwares. • Knowledge of the use of pharmacokinetic analysis for evaluation of toxicological data and performing safety assessment of test substances. • Opportunities of presenting the analyzed data and reporting research findings Requirements: The candidates must be currently enrolled in a graduate or undergraduate program majoring in a discipline of science such as biology and chemistry. Coursework in pharmacology, toxicology, pharmacokinetics, physiology or related discipline is preferred but not required. The position will be confirmed upon management review. Interested candidates should send their resume to Dr. Shruti Kabadi at [log in to unmask] no later than March 27, 2017. If you have any questions, please feel free to contact Dr. Kabadi directly. Duration: 3 months (Stipend provided: $800 per week) Appointment Period: June 1, 2017 to August 31, 2017 Application Deadline: March 27, 2017 Event Location: FDA/CFSAN/OFAS, 5001 Campus Drive, College Park, MD 20740 Contact Person: Shruti V. Kabadi, Ph.D. Contact Email: [log in to unmask] Contact Phone Number: (240) 402-6593