On behalf of Dr. Denise Croker at University of Limerick.

Dr Denise is seeking potential candidates for SSPC-Associated PhD position in Hybrid Model predictive control of continuous crystallization with integrated wet milling.

The Synthesis and Solid State Pharmaceutical Centre (SSPC), a Global Hub
of Pharmaceutical Process Innovation and Advanced Manufacturing, funded by Science Foundation Ireland and industry, is a unique collaboration between 24 industry partners, 9 research performing organisations and 12 international academic collaborators. SSPC operations team are based in The Bernal Institute, Analog Devices Building, University of Limerick.

The project will explore continuous crystallization of an Active Pharmaceutical Ingredient with an integrated wet mill using closed loop control and online Process Analytical Techniques (PAT). The initial phase of the project will involve selection of a suitable model API system to work with, characterisation of the experimental set up (Mettler Toledo Optimax with IKA Magic Mill; potential for additional vessel with heating and agitation control), and integration of Perceptive Engineering’s PharmaMV software platform. PAT measurements such as Focused Beam Reflectance Measurement (FBRM) and Infrared Spectrometry will be used to monitor product quality in-situ.

Subsequent experiment work will be completed to establish models that characterise the crystallization and milling processes. PharmaMV will be used to develop dynamic statistical models to describe the impact of key process parameters on measured product quality attributes (namely, particle size distribution). The inclusion of a dissolution vessel in the closed loop experimental set-up will be investigated as an additional actuator to product quality. The ultimate goal of the project will be to develop and demonstrate a Model Predictive Controller for the crystallization-milling-annealing loop to provide tight control of Critical Quality Attributes such as particle size.

Supervisors: Gavin Walker/Denise Croker/Perceptive Engineering Ltd
Based at: University of Limerick
For more information: Denise.Croker@ul.ie

For more details on the position and SSPC kindly follow the link below:

Best regards,

Vamsi Kamaraju, BE, PhD
Research Engineer

Applied Process Company Ltd
Building 11, Cherrywood Business Park, Loughlinstown, Co Dublin D18 DH50
M: (0)85 869 4252